Glycogen Metabolism Animation

Every glycogen molecule has at its core a glycogenin protein a glycoprotein which remains attached to the reducing end of glycogen during its degradation. That is either by converting glycogen glucose glucogenolysis or by converting carbs aas pyruvate or lactate glucose gluconeogenesis. For de novo glycogen synthesis to proceed the first few glucose residues are attached to a protein known as glycogeninglycogenin binds to actin filaments therough a domain in the c terminus of the protein.

The cascade shown here is identical to that shown in slide 754 all the way from the hormones to the activation of protein kinase a.

Glycogen metabolism animation. How do these apply to glycolysis and gluconeogenesis. Glycogen synthesis glycogenin in de novo glycogen synthesis. The interaction of glycogenin with actin filaments is required to initiate the synthesis of glycogen. What are the major forms of regulation in metabolism.

The synthesis of glycogen does not usually involve the de novo formation of glycogen but consists in lengthening of existing glycogen molecules by adding glucosyl residues. The activated kinase directly phosphorylates glycogen synthase which inactivates that enzyme. Hormonal control of glycogen metabolism is similar to that of gluconeogenesis.